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Cardiovasc Res. 2012 May 1;94(2):293-303. doi: 10.1093/cvr/cvs109. Epub 2012 Mar 2.

Novel therapeutic approaches to post-infarction remodelling.

Author information

1
Klinik fuer Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany.

Abstract

Adverse cardiac remodelling is a major cause of morbidity and mortality following acute myocardial infarction (MI). Mechanical and neurohumoral factors involved in structural and molecular post-infarction remodelling were important targets in research and treatment for years. More recently, therapeutic strategies that address myocardial regeneration and pathophysiological mechanisms of infarct wound healing appear to be useful novel tools to prevent progressive ventricular dilation, functional deterioration, life-threatening arrhythmia, and heart failure. This review provides an overview of future and emerging therapies for cardiac wound healing and remodelling after MI.

PMID:
22387461
DOI:
10.1093/cvr/cvs109
[Indexed for MEDLINE]

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