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Biochim Biophys Acta. 2012 Jul;1818(7):1642-7.

Estimation of the subunit stoichiometry of the membrane-associated daptomycin oligomer by FRET.

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1
Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada.

Abstract

Daptomycin is a lipopeptide antibiotic that kills Gram-positive bacteria by depolarizing their cell membranes. This antibacterial action of daptomycin is correlated with the formation of membrane-associated oligomers. We here examine the number of subunits contained in one oligomer using fluorescence resonance energy transfer (FRET). The results suggest that the oligomer contains approximately 6 to 7 subunits, or possibly twice this number if it spans both membrane monolayers.

PMID:
22387459
DOI:
10.1016/j.bbamem.2012.02.019
[Indexed for MEDLINE]
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