Format

Send to

Choose Destination
Leuk Res. 2012 May;36(5):594-7. doi: 10.1016/j.leukres.2012.02.009. Epub 2012 Mar 3.

Could age modify the effect of genetic variants in IL6 and TNF-α genes in multiple myeloma?

Author information

1
Department of Biology, Genetics division, University of Pisa, Italy. a.martino@dkfz-heidelberg.de

Abstract

Cytokines play a central role in multiple myeloma (MM) pathogenesis thus genetic variations within cytokines coding genes could influence MM susceptibility and therapy outcome. We investigated the impact of 8 SNPs in these genes in 202 MM cases and 235 controls also evaluating their impact on therapy outcome in a subset of 91 patients. Despite the overall negative findings, we found a significant age-modified effect of IL6 and TNF-α SNPs, on MM risk and therapy outcome, respectively. Therefore, this observation suggests that genetic variation in inflammation-related genes could be an important mediator of the complex interplay between ageing and cancer.

PMID:
22387051
DOI:
10.1016/j.leukres.2012.02.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center