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Leuk Res. 2012 May;36(5):594-7. doi: 10.1016/j.leukres.2012.02.009. Epub 2012 Mar 3.

Could age modify the effect of genetic variants in IL6 and TNF-α genes in multiple myeloma?

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Department of Biology, Genetics division, University of Pisa, Italy.


Cytokines play a central role in multiple myeloma (MM) pathogenesis thus genetic variations within cytokines coding genes could influence MM susceptibility and therapy outcome. We investigated the impact of 8 SNPs in these genes in 202 MM cases and 235 controls also evaluating their impact on therapy outcome in a subset of 91 patients. Despite the overall negative findings, we found a significant age-modified effect of IL6 and TNF-α SNPs, on MM risk and therapy outcome, respectively. Therefore, this observation suggests that genetic variation in inflammation-related genes could be an important mediator of the complex interplay between ageing and cancer.

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