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Cell Calcium. 2012 Jul;52(1):52-6. doi: 10.1016/j.ceca.2012.02.003. Epub 2012 Mar 3.

Mitochondrial regulation of CRAC channel-driven cellular responses.

Author information

1
Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, UK.

Abstract

One widespread and conserved Ca(2+) entry pathway in eukaryotic cells is the store-operated CRAC channel and Ca(2+) entry through these channels activates a disparate array of cellular responses. Under physiological conditions, mitochondria are important regulators of CRAC channel gating. Through these actions, mitochondria help control a range of spatially and temporally distinct CRAC channel-driven responses including enzyme activation, secretion, intercellular communication through paracrine signals and gene expression.

PMID:
22387012
DOI:
10.1016/j.ceca.2012.02.003
[Indexed for MEDLINE]

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