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J Crit Care. 2012 Oct;27(5):527.e1-6. doi: 10.1016/j.jcrc.2012.01.002. Epub 2012 Mar 3.

Decreased plasma gelsolin is associated with 1-year outcome in patients with traumatic brain injury.

Author information

1
Department of Neurosurgery, Affiliated Taizhou Municipal Hospital, Taizhou University, Jiaojiang District, Taizhou 318000, China. taizhoujinyong@163.com

Abstract

PURPOSE:

Decreased plasma gelsolin level has been associated with 1-month mortality after traumatic brain injury (TBI). Thus, we investigated the ability of gelsolin to predict 1-year mortality and functional outcome in these patients.

METHODS:

One hundred fourteen healthy controls and 114 patients with acute severe TBI were included in this study. Plasma gelsolin concentration on admission was measured by ELISA.

RESULTS:

Fifty-five patients (48.2%) had unfavorable outcome (Glasgow Outcome Scale score of 1-3) and 38 patients (33.3%) died in 1 year after TBI. Upon admission, plasma gelsolin level in patients was substantially lower than that in healthy controls. A multivariate analysis selected plasma gelsolin level as an independent predictor for 1-year unfavorable outcome and mortality of patients. A receiver operating characteristic curve analysis showed plasma gelsolin level predicted 1-year unfavorable outcome and mortality statistically significantly. The predictive value of the gelsolin concentration was thus similar to that of Glasgow Coma Scale (GCS) score. In a combined logistic-regression model, gelsolin did not statistically significantly improve the area under curve of GCS score.

CONCLUSIONS:

Plasma gelsolin level is a useful, complementary tool to predict functional outcome and mortality 1 year after TBI.

PMID:
22386223
DOI:
10.1016/j.jcrc.2012.01.002
[Indexed for MEDLINE]

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