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Cell Stem Cell. 2012 Mar 2;10(3):231-2. doi: 10.1016/j.stem.2012.02.008.

Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate.

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State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China.


Coordinated interactions between signaling networks govern the balance of cell fate decisions in human embryonic stem cells. In this issue, Singh et al. (2012) report that PI3K/Akt signaling switches Activin/Smad activity between pro-self-renewal and prodifferentiation by regulating ERK and GSK3β/β-catenin signaling.

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