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Cell Stem Cell. 2012 Mar 2;10(3):231-2. doi: 10.1016/j.stem.2012.02.008.

Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate.

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1
State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China. ygchen@tsinghua.edu.cn

Abstract

Coordinated interactions between signaling networks govern the balance of cell fate decisions in human embryonic stem cells. In this issue, Singh et al. (2012) report that PI3K/Akt signaling switches Activin/Smad activity between pro-self-renewal and prodifferentiation by regulating ERK and GSK3β/β-catenin signaling.

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