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Zh Vyssh Nerv Deiat Im I P Pavlova. 2011 Nov-Dec;61(6):736-41.

[Impairments of conditioned behavior in adult rats induced by interleukine-1beta treatment in early postnatal ontogenesis].

[Article in Russian]

Abstract

Impairments of cognitive functions in children and adolescents are often consequences ofperinatal pathology (natal injuries, ischemia, hypoxia, infection and allergic diseases), which are accompanied by enhanced production ofproinflammatory cytokine interleukine-1beta. In this work it was shown that treatment with interleukine-1beta during the third week of life impaired active and passive avoidance conditioning in adult rats at the age of 60-70 days.

PMID:
22384734
[Indexed for MEDLINE]

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