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Clin Exp Reprod Med. 2011 Mar;38(1):1-5. doi: 10.5653/cerm.2011.38.1.1. Epub 2011 Mar 31.

Small GTPases and formins in mammalian oocyte maturation: cytoskeletal organizers.

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Department of Biomedical Science & Technology, Institute of Biomedical Science & Technology, Research Center for Transcription Control, Konkuk University, Seoul, Korea.


The maturation process of mammalian oocytes accompanies an extensive rearrangement of the cytoskeleton and associated proteins. As this process requires a delicate interplay between the cytoskeleton and its regulators, it is often targeted by various external and internal adversaries that affect the congression and/or segregation of chromosomes. Asymmetric cell division in oocytes also requires specific regulators of the cytoskeleton, including formin-2 and small GTPases. Recent literature providing clues regarding how actin filaments and microtubules interact during spindle migration in mouse oocytes are highlighted in this review.


Formin; GTP Phosphohydrolases; Human; Mice; Oocyte; Spindle

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