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Science. 2012 Jun 8;336(6086):1274. doi: 10.1126/science.1218713. Epub 2012 Mar 1.

Crystal structure of human enterovirus 71.

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1
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.

Abstract

Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the "pocket factor," a small molecule that stabilizes the virus, is partly exposed on the floor of the "canyon." Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket.

PMID:
22383808
PMCID:
PMC3448362
DOI:
10.1126/science.1218713
[Indexed for MEDLINE]
Free PMC Article
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