Format

Send to

Choose Destination
Biol Psychiatry. 2012 May 15;71(10):922-30. doi: 10.1016/j.biopsych.2012.01.020. Epub 2012 Feb 28.

MAGI1 copy number variation in bipolar affective disorder and schizophrenia.

Author information

1
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. robert.karlsson@ki.se

Abstract

BACKGROUND:

Bipolar affective disorder (BPAD) and schizophrenia (SZ) are devastating psychiatric disorders that each affect about 1% of the population worldwide. Identification of new drug targets is an important step toward better treatment of these poorly understood diseases.

METHODS:

Genome-wide copy number variation (CNV) was assessed and variants were ranked by co-occurrence with disease in 48 BPAD families. Additional support for involvement of the highest-ranking CNV from the family-based analysis in psychiatric disease was obtained through analysis of 4084 samples with BPAD, SZ, or schizoaffective disorder. Finally, a pooled analysis of in-house and published datasets was carried out including 10,925 cases with BPAD, SZ, or schizoaffective disorder and 16,747 controls.

RESULTS:

In the family-based analysis, an approximately 200 kilobase (kb) deletion in the first intron of the MAGI1 gene was identified that segregated with BPAD in a pedigree (six out of six affected individuals; parametric logarithm of the odds score = 1.14). In the pooled analysis, seven additional insertions or deletions over 100 kb were identified in MAGI1 in cases, while only two such CNV events were identified in the same gene in controls (p = .023; Fisher's exact test). Because earlier work had identified a CNV in the close relative MAGI2 in SZ, the study was extended to include MAGI2. In the pooled analysis of MAGI2, two large deletions were found in cases, and two duplications were detected in controls.

CONCLUSIONS:

Results presented herein provide further evidence for a role of MAGI1 and MAGI2 in BPAD and SZ etiology.

PMID:
22381734
DOI:
10.1016/j.biopsych.2012.01.020
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center