Format

Send to

Choose Destination
Schizophr Res. 2012 May;137(1-3):166-8. doi: 10.1016/j.schres.2012.02.009. Epub 2012 Mar 3.

Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition.

Author information

1
School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada. jhusted@uwaterloo.ca

Abstract

There are few studies of environmental factors in familial forms of schizophrenia. We investigated whether childhood adversity or environmental factors were associated with schizophrenia in a familial sample where schizophrenia is associated with the NOSA1P gene. We found that a cumulative adversity index including childhood illness, family instability and cannabis use was significantly associated with narrow schizophrenia, independent of NOSA1P risk genotype, previously measured childhood trauma, covariates and familial clustering (adjusted odds ratio (95% confidence interval)=1.55 (1.01, 2.38)). The results provide further support that early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition.

PMID:
22381191
PMCID:
PMC3436901
DOI:
10.1016/j.schres.2012.02.009
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center