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Trends Biochem Sci. 1990 Sep;15(9):342-6.

Protein kinase recognition sequence motifs.

Author information

1
St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.

Abstract

Protein kinases play a crucial role in the regulation of many cellular processes. They alter the functions of their target proteins by phosphorylating specific serine, threonine and tyrosine residues. Identification of phosphorylation site sequences and studies with corresponding model peptides have provided clues to how these important enzymes recognize their substrate proteins. This knowledge has made it possible to identify potential sites of phosphorylation in newly sequenced proteins as well as to construct specific model substrates and inhibitors.

PMID:
2238044
[Indexed for MEDLINE]

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