Objective: To describe the relationship between referred itch (mitempfindung) stimulus and referral points and acupuncture meridians, noting that the neuroanatomical mechanism of mitempfindung has never previously been satisfactorily explained.
Methods: Analysis of clinical findings in the author as well as subjects in four previously described studies, comparing proportions in each of five groups.
Results: Ninety-two per cent (range 85-94%) of mitempfindung point pairs (stimulus and referral) aligned to a recognised acupuncture meridian with no statistical difference (p<0.05) between the five data sources.
Conclusion: While previous authors have speculated on an association between mitempfindung and acupuncture, this is the first description of a relationship between stimulus and referral points and acupuncture meridians. The author suggests that the transmission of mitempfindung along acupuncture meridians may involve a series of C-fibre-Merkel cell relays, with the final referred itch sensation caused by substance P release triggering mast cell degranulation.