Format

Send to

Choose Destination
Hepatology. 2012 Oct;56(4):1567-74. doi: 10.1002/hep.25674. Epub 2012 Sep 11.

Chronic inflammation, immune escape, and oncogenesis in the liver: a unique neighborhood for novel intersections.

Author information

1
Cancer and Inflammation Program, NCI, Frederick, MD 21702, USA.

Abstract

Sustained hepatic inflammation, driven by alcohol consumption, nonalcoholic fatty liver disease, and/or chronic viral hepatitis (hepatitis B and C), results in damage to parenchyma, oxidative stress, and compensatory regeneration/proliferation. There is substantial evidence linking these inflammation-associated events with the increased incidence of hepatocellular carcinogenesis. Although acute liver inflammation can play a vital and beneficial role in response to liver damage or acute infection, the effects of chronic liver inflammation, including liver fibrosis and cirrhosis, are sufficient in a fraction of individuals to initiate the process of transformation and the development of hepatocellular carcinoma. This review highlights immune-dependent mechanisms that may be associated with hepatocellular oncogenesis, including critical transformative events/pathways in the context of chronic inflammation and subverted tolerogenesis.

PMID:
22378061
PMCID:
PMC3381981
DOI:
10.1002/hep.25674
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center