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Ophthalmologica. 2012;228(1):26-35. doi: 10.1159/000335961. Epub 2012 Feb 22.

Two-year randomized, placebo-controlled study of black currant anthocyanins on visual field in glaucoma.

Author information

1
Department of Ophthalmology, Sapporo Medical University School of Medicine, Sapporo, Japan. ooguro @ sapmed.ac.jp

Abstract

AIM:

To examine the influence of the black currant anthocyanins (BCACs) on the disease progression of open-angle glaucoma (OAG), a randomized, placebo-controlled, double-masked trial was made in 38 patients with OAG treated by antiglaucoma drops.

METHODS:

BCACs (50 mg/day, n = 19) or their placebos (n = 19) were orally administered once daily for a 24-month period. Systemic blood pressure, pulse rates, intraocular pressure (IOP), ocular blood circulation by laser-speckle flowgraphy, and Humphrey visual field mean deviation (MD) were measured during the 24-month period.

RESULTS:

As a main outcome measurement, we evaluated the difference between the groups in MD deterioration in the eye with a better MD from the trial's baseline through 24 months. A statistically significant difference was observed between the treatment groups in mean change from baseline in MD 24 months after therapy (p = 0.039, unpaired t test). Upon administration of BCACs, the ocular blood flows during the 24-month observational period increased in comparison with placebo-treated patients. However, no significant changes were observed in systemic and ocular conditions including IOP during the 24-month period.

CONCLUSIONS:

Our results suggest that oral administration of BCACs may be a safe and promising supplement for patients with OAG in addition to antiglaucoma medication.

PMID:
22377796
DOI:
10.1159/000335961
[Indexed for MEDLINE]

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