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Emerg Infect Dis. 2012 Mar;18(3):449-57. doi: 10.3201/eid1803.110728.

Lineage-specific virulence determinants of Haemophilus influenzae biogroup aegyptius.

Author information

1
Imperial College London, Medicine, St Mary’s Hospital campus, Norfolk Place, London W2 1PG, UK.

Abstract

An emergent clone of Haemophilus influenzae biogroup aegyptius (Hae) is responsible for outbreaks of Brazilian purpuric fever (BPF). First recorded in Brazil in 1984, the so-called BPF clone of Hae caused a fulminant disease that started with conjunctivitis but developed into septicemic shock; mortality rates were as high as 70%. To identify virulence determinants, we conducted a pan-genomic analysis. Sequencing of the genomes of the BPF clone strain F3031 and a noninvasive conjunctivitis strain, F3047, and comparison of these sequences with 5 other complete H. influenzae genomes showed that >77% of the F3031 genome is shared among all H. influenzae strains. Delineation of the Hae accessory genome enabled characterization of 163 predicted protein-coding genes; identified differences in established autotransporter adhesins; and revealed a suite of novel adhesins unique to Hae, including novel trimeric autotransporter adhesins and 4 new fimbrial operons. These novel adhesins might play a critical role in host-pathogen interactions.

PMID:
22377449
PMCID:
PMC3309571
DOI:
10.3201/eid1803.110728
[Indexed for MEDLINE]
Free PMC Article

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