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Curr Opin Neurobiol. 2012 Aug;22(4):660-9. doi: 10.1016/j.conb.2012.02.001. Epub 2012 Feb 28.

Cellular-based modeling of oscillatory dynamics in brain networks.

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Toronto Western Research Institute, University Health Network, and University of Toronto, Canada.


Oscillatory, population activities have long been known to occur in our brains during different behavioral states. We know that many different cell types exist and that they contribute in distinct ways to the generation of these activities. I review recent papers that involve cellular-based models of brain networks, most of which include theta, gamma and sharp wave-ripple activities. To help organize the modeling work, I present it from a perspective of three different types of cellular-based modeling: 'Generic', 'Biophysical' and 'Linking'. Cellular-based modeling is taken to encompass the four features of experiment, model development, theory/analyses, and model usage/computation. The three modeling types are shown to include these features and interactions in different ways.

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