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Curr Med Chem. 2012;19(12):1864-9.

Cognitive, psychological and psychiatric effects of ionizing radiation exposure.

Author information

  • 1Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Roma, 67, I- 56100 Pisa, Italy. dmarazzi@psico.med.unipi.it

Abstract

Radiation exposure leads to an increased risk for cancer and, possibly, additional ill-defined non-cancer risk, including atherosclerotic, cardiovascular, cerebro-vascular and neurodegenerative effects. Studies of brain irradiation in animals and humans provide evidence of apoptosis, neuro-inflammation, loss of oligo-dendrocytes precursors and myelin sheaths, and irreversible damage to the neural stem compartment with long-term impairment of adult neurogenesis. With the present paper we aim to present a comprehensive review on brain effects of radiation exposure, with a special focus on its impact on cognitive processes and psychological functions, as well as on their possible role in the pathophysiology of different psychiatric disorders.

PMID:
22376039
[PubMed - indexed for MEDLINE]
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