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Nat Cell Biol. 2012 Feb 29;14(3):224-30. doi: 10.1038/ncb2420.

Multiple modes of cytoplasmic dynein regulation.

Author information

1
Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA. rv2025@columbia.edu

Abstract

In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high- and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.

PMID:
22373868
DOI:
10.1038/ncb2420
[Indexed for MEDLINE]

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