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Cell Cycle. 2012 Feb 15;11(4):683-6. doi: 10.4161/cc.11.4.19130.

The emerging role of the TGFβ tumor suppressor pathway in pancreatic cancer.

Author information

  • 1Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR1068 Inserm, Institut Paoli-Calmettes, Marseille, France.

Abstract

Pancreatic adenocarcinoma is one of the most aggressive human cancers. It displays many different chromosomal abnormalities and mutations. To design new therapeutic strategies, it is important to identify the signaling pathways and gene networks within this apparent complexity that are predominantly altered. The TGFβ signaling pathway and associated transcription network emerges as a central actor of pancreatic oncogenesis. Its tumor suppressor function in this tissue can be affected by several alterations.

PMID:
22373528
DOI:
10.4161/cc.11.4.19130
[PubMed - indexed for MEDLINE]
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