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Blood. 2012 May 24;119(21):4889-97. doi: 10.1182/blood-2011-10-388736. Epub 2012 Feb 27.

CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential.

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1
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

Abstract

A unique subset of CD86(-) HSCs was previously discovered in mice that were old or chronically stimulated with lipopolysaccharide. Functionally defective HSCs were also present in those animals, and we now show that CD86(-) CD150(+) CD48(-) HSCs from normal adult mice are particularly poor at restoring the adaptive immune system. Levels of the marker are high on all progenitors with lymphopoietic potential, and progressive loss helps to establish relations between progenitors corresponding to myeloid and erythroid lineages. CD86 represents an important tool for subdividing HSCs in several circumstances, identifying those unlikely to generate a full spectrum of hematopoietic cells.

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PMID:
22371880
PMCID:
PMC3367893
DOI:
10.1182/blood-2011-10-388736
[Indexed for MEDLINE]
Free PMC Article
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