Format

Send to

Choose Destination
See comment in PubMed Commons below
Arch Neurol. 2012 Jun;69(6):752-6. doi: 10.1001/archneurol.2011.2956.

Anti-myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritis.

Author information

1
Division of Pediatric Neurology and Inherited Metabolic Disorders, Department of Pediatrics IV, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria. kevin.rostasy@uki.at

Abstract

OBJECTIVE:

To study the humoral immune response directed at myelin oligodendrocyte glycoprotein (MOG)in pediatric patients with isolated and recurrent optic neuritis(ON).

DESIGN:

Observational prospective case series.

SETTING:

Six pediatric hospitals in Germany and Austria.

PATIENTS:

Thirty-seven patients 18 years or younger with single or recurrent episodes of ON were recruited from 6 different hospitals.

MAIN OUTCOME MEASURES:

Clinical features, magnetic resonance imaging findings, intrathecal IgG synthesis,and outcome were recorded. A live cell–based immunofluorescence assay was used to measure serum IgG antibodies to MOG and aquaporin 4.

RESULTS:

A single episode of ON was observed in 10 patients,and 15 experienced 2 to 12 episodes. The acute episode of ON was part of a clinically isolated syndrome in 12 patients, of whom 8 were subsequently classified as having multiple sclerosis. High-titer serum MOG-IgG antibodies (1:160) were detected in 17 patients (46%).In addition, high titers of MOG-IgG antibodies were more frequently observed in 12 of the 15 patients with recurrent episodes of ON (80%; median titer, 1:640)compared with 2 of the 10 patients with monophasic ON(20%; median titer, 0) and 3 of the 12 patients with ON as part of a clinically isolated syndrome (25%; median titer, 0).

CONCLUSION:

High-titer MOG-IgG antibodies are predominantly detected in pediatric patients with recurrent ON, indicating that anti-MOG-specific antibodies may exert a direct role in the pathogenesis of ON in this subgroup.

PMID:
22371853
DOI:
10.1001/archneurol.2011.2956
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center