Send to

Choose Destination
J Indian Soc Periodontol. 2011 Oct;15(4):398-401. doi: 10.4103/0972-124X.92578.

To evaluate the antigingivitis and antipalque effect of an Azadirachta indica (neem) mouthrinse on plaque induced gingivitis: A double-blind, randomized, controlled trial.

Author information

Department of Periodontics, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.



Azadirachta indica (neem), a Meliaceae family tree, has been used in India for several decades for the treatment of several diseases in medicine and dentistry. Neem has been considered to have antiseptic activity, but still its use for the treatment of gingivitis and periodontitis is not very clear. Hence, the purpose of the present study was to assess the efficacy of neem based mouth rinse regarding its antigingivitis effect.


Forty five subjects with plaque induced gingivitis were selected for the study. They were equally divided into three groups. Group I patients were asked to rinse with 15 ml of neem mouthwash twice daily, group II with 15 ml of chlorhexidine mouthwash twice daily, and group III with 15 ml of saline twice daily. The three groups were asked to perform the routine oral hygiene procedures thought out the study period. Bleeding on probing and gingivitis were evaluated by Muhlemann and Son's Sulcus bleeding index (1971) and Loe and Sillness gingival index (1963), respectively, at base line, after every week till one month.


Our result showed that an A. indica mouthrinse is equally effective in reducing periodontal indices as Chlorhexidine. The results demonstrated a significant reduction of gingival, bleeding, and plaque indices in both groups over a period of 21 days as compared to placebo.


A. indica-based mouth rinse is equally efficacious with fewer side effects as compared to chlorhexidine and may be used as an adjunct therapy in treating plaque induced gingivitis.


Azadirachta indica; chlorhexidin gluconate; plaque index

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
Loading ...
Support Center