Autoimmune polyendocrine syndrome-3 in a patient with late-onset multiple sclerosis

Neurologist. 2012 Mar;18(2):83-4. doi: 10.1097/NRL.0b013e318248ea2a.

Abstract

We present here the rare case of a 73-year-old patient with very late-onset multiple sclerosis who developed autoimmune polyendocrine syndrome (APS)-3. Despite only a few reports describing the association between multiple sclerosis and APS, both of these diseases have been shown to be associated with HLA-DR4. Intriguingly, the HLA genotype profile of this patient included HLA-DR4 which, fine mapped to the DRB1*0405-DQA1*0303-DQB1*0401 extended haplotype, reported to be a susceptibility haplotype for APS-3 in Japan. This unique genetic background might explain the clinical picture of this patient.

Publication types

  • Case Reports

MeSH terms

  • Age of Onset
  • Aged
  • Asian People / genetics
  • Female
  • Genetic Predisposition to Disease / genetics*
  • HLA-DR4 Antigen / genetics
  • Humans
  • Multiple Sclerosis / complications*
  • Polyendocrinopathies, Autoimmune / complications*
  • Polyendocrinopathies, Autoimmune / diagnosis
  • Polyendocrinopathies, Autoimmune / genetics*

Substances

  • HLA-DR4 Antigen