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Diabetologia. 2012 Jun;55(6):1633-40. doi: 10.1007/s00125-012-2502-8. Epub 2012 Feb 26.

Microvascular autoregulation in children and adolescents with type 1 diabetes mellitus.

Author information

1
Department of Medicine II, Division of Angiology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.

Abstract

AIMS/HYPOTHESIS:

Deterioration of microvascular function may have an early onset in individuals with type 1 diabetes mellitus. We hypothesised that microvascular autoregulation is impaired in children with type 1 diabetes and can be detected non-invasively by postocclusive reactive hyperaemia (PORH).

METHODS:

Microvascular autoregulation was assessed in 58 children with type 1 diabetes and 58 age- and sex-matched healthy controls by PORH using laser Doppler fluxmetry. Baseline perfusion, biological zero (defined as a 'no flow' laser Doppler signal during suprasystolic occlusion), peak perfusion following occlusion, time to peak and recovery time (time until baseline perfusion is resumed) were recorded and compared between the groups.

RESULTS:

Peak perfusion was higher in children with type 1 diabetes than in healthy controls (1.7 ± 0.93 AU [arbitrary units] vs 1.29 ± 0.46 AU; p = 0.004), and biological zero was lower in children with type 1 diabetes vs controls (0.14 ± 0.04 AU vs 0.19 ± 0.04 AU; p < 0.0001). No differences were seen between the groups in baseline perfusion, time to peak during PORH and recovery time following PORH.

CONCLUSIONS/INTERPRETATION:

PORH reveals impaired microvascular autoregulation in children with type 1 diabetes. The higher peak perfusion might reflect a decline in the vasoconstrictive ability of arteriolar smooth muscle cells upstream of capillary beds in children with type 1 diabetes.

PMID:
22366881
DOI:
10.1007/s00125-012-2502-8
[Indexed for MEDLINE]

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