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J Glaucoma. 2013 Jun-Jul;22(5):384-9. doi: 10.1097/IJG.0b013e31824c9423.

Comparison of optic nerve head parameter measurements obtained by time-domain and spectral-domain optical coherence tomography.

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GB Bietti Eye Foundation-IRCCS, Rome, Italy.



To compare the measurements of the optic nerve head (ONH) parameters provided by time-domain (TD) and spectral-domain (SD) optical coherence tomography (OCT).


Four ONH parameters were analyzed: optic disc area, rim area, cup-to-disc area ratio (CDR), and vertical cup-to-disc ratio (VCDR). Stratus OCT and Cirrus HD-OCT were used to obtain measurements by TD-OCT and SD-OCT, respectively. Stratus OCT measurements were collected before and after manual correction of the ONH edges.


Twenty healthy participants and 20 patients with glaucomatous eyes were enrolled. Although manual correction of Stratus OCT measurements reduced the differences compared with Cirrus HD-OCT, the latter measured a smaller mean disc area than Stratus OCT in healthy (2.02±0.31 vs. 2.18±0.29 mm2, P=0.0003) and glaucomatous eyes (1.92±0.35 vs. 2.19±0.38 mm2, P<0.0001). Cirrus HD-OCT measured a smaller rim area than Stratus OCT in healthy (1.31±0.30 vs. 1.56±0.32 mm2, P<0.0001) and glaucomatous eyes (0.80±0.25 vs. 0.97±0.36 mm2, P=0.0052), a higher CDR (0.55±0.11 vs. 0.49±0.11, P<0.0001) and VCDR in healthy eyes (0.55±0.11 vs. 0.49±0.11, P<0.0001), and a higher CDR in glaucomatous eyes (0.74±0.10 vs. 0.58±0.18, P<0.0001). No statistically significant differences were detected for VCDR in glaucomatous eyes. All measured values showed good correlation (r≥0.70). Large 95% limits of agreement between the 2 devices were found for most parameters.


ONH parameter measurements provided by TD-OCT and SD-OCT show significant differences and cannot be considered interchangeable.

[Indexed for MEDLINE]

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