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Clin Biochem. 2012 May;45(7-8):525-9. doi: 10.1016/j.clinbiochem.2012.02.004. Epub 2012 Feb 16.

Characterization of metalloproteinases, oxidative status and inflammation levels in the different stages of fibrosis in HCV patients.

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1
INT "G. Pascale", CROM-Oncology Research Centre of Mercogliano, Mercogliano, Italy.

Abstract

OBJECTIVES:

This study was aimed at searching noninvasive markers of the transition from mild to severe fibrosis stage in HCV patients undergoing hepatic fibrosis.

DESIGN AND METHODS:

Thirty-three patients affected by chronic HCV vs. twenty healthy donors were evaluated for the serum levels of several circulating matrix metalloproteinases (MMPs), TRAIL and β-NGF by multiplex biometric ELISA based immunoassay and anti- and pro-oxidant status (d-ROMs, BAP and NO) using a Diacron automated method.

RESULTS:

HCV patients displayed increased expression levels of MMP-8, MMP-9, TRAIL and β-NGF, and an imbalance between pro- and antioxidant status, that contribute to liver fibrosis.

CONCLUSIONS:

Since the determination of these parameters represents a reliable and easily applicable method, these parameters are suggested as serum surrogate markers for HCV patients in the routine clinical practice.

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