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J Vasc Interv Radiol. 2012 Mar;23(3):417-22. doi: 10.1016/j.jvir.2011.12.007.

Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon: successful treatment with embolization and vincristine in two newborns.

Author information

1
Vascular Anomalies Center, Hospital Italiano, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina. ricardo.garciamonaco@hospitalitaliano.org.ar

Abstract

Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor and has a high mortality in newborns when associated with Kasabach-Merritt syndrome (KMS). In two newborns with KHE and severe KMS refractory to medical treatment, emergency embolization led to clinical improvement in the acute neonatal setting by reducing tumor volume, increasing the platelet count, and improving other clotting parameters. Systemic vincristine treatment was added for further tumor control. Both patients remained symptom-free at long-term follow-up.

PMID:
22365299
DOI:
10.1016/j.jvir.2011.12.007
[Indexed for MEDLINE]

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