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Chem Commun (Camb). 2012 Apr 4;48(27):3339-41. doi: 10.1039/c2cc00027j. Epub 2012 Feb 24.

Isotope-coded, fluorous photoaffinity labeling reagents.

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1
Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

A pair of isotope-coded, fluorous photoaffinity labeling reagents has been developed and coupled with a peptide. The modified peptides form adducts with methanol upon light illumination, which show characteristic isotope labeling patterns in mass spectra and can be separated from other peptides through fluorous silica.

PMID:
22363935
DOI:
10.1039/c2cc00027j
[Indexed for MEDLINE]
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