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PLoS One. 2012;7(2):e31245. doi: 10.1371/journal.pone.0031245. Epub 2012 Feb 17.

Methicillin-resistant Staphylococcus aureus ST9 in pigs in Thailand.

Author information

1
Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark. JRL@ssi.dk

Abstract

BACKGROUND:

Methicillin-resistant Staphylococcus aureus (MRSA) is an important nosocomial and community-associated pathogen. Recently, livestock-associated MRSA (LA-MRSA) has emerged and disseminated in Europe and North America and now constitutes a considerable zoonotic burden in humans with risk factors of pig exposure, whereas the extent of the livestock reservoir is relatively unknown on other continents.

METHODOLOGY/PRINCIPAL FINDINGS:

From March through April 2011, MRSA was identified in pigs from 3 out of 30 production holdings in Chang Mai Province, Thailand. Representative isolates were subjected to molecular characterization and antimicrobial susceptibility testing; all isolates had genotypic and phenotypic characteristics of LA-MRSA previously characterized in the region: they belonged to ST9, lacked the lukF-lukS genes encoding Panton-Valentine leukocidin, and were resistant to multiple non-β-lactam antimicrobials. However, unlike other Asian LA-MRSA-ST9 variants, they were spa type t337 and harbored a different staphylococcal cassette chromosome mec IX.

CONCLUSIONS/SIGNIFICANCE:

A novel MRSA-ST9 lineage has been established in the pig population of Thailand, which differs substantially from LA-MRSA lineages found in other areas of the continent. The emergence of novel LA-MRSA lineages in the animal agriculture setting is worrisome and poses a serious threat to global public health.

PMID:
22363594
PMCID:
PMC3281948
DOI:
10.1371/journal.pone.0031245
[Indexed for MEDLINE]
Free PMC Article

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