Format

Send to

Choose Destination
See comment in PubMed Commons below
Front Neurol. 2012 Feb 20;3:22. doi: 10.3389/fneur.2012.00022. eCollection 2012.

Deep Brain Stimulation of the Pallidum is Effective and Might Stabilize Striatal D(2) Receptor Binding in Myoclonus-Dystonia.

Author information

  • 1Department of Neurology, Academic Medical Centre, University of Amsterdam Amsterdam, Netherlands.

Abstract

PURPOSE:

To assess clinical efficacy of deep brain stimulation (DBS) of the pallidum in Myoclonus-Dystonia (M-D) patients, and to compare pre- and post-operative striatal dopamine D2 receptor availability.

METHODS:

Clinical parameters were scored using validated rating scales for myoclonus and dystonia. Dopamine D2 receptor binding of three patients was studied before surgery and approximately 2 years post-operatively using 123-I-iodobenzamide Single Photon Emission Computed Tomography. Two patients who did not undergo surgery served as controls.

RESULTS:

Clinically, the three M-D patients improved 83, 17, and 100%, respectively on the myoclonus rating scale and 78, 23, and 65% on the dystonia rating scale after DBS. Dopamine D2 receptor binding did not change after surgery. In the two control subjects, binding has lowered further.

CONCLUSION:

These findings confirm that DBS of the pallidum has beneficial effects on motor symptoms in M-D and suggest this procedure might stabilize dopamine D2 receptor binding.

KEYWORDS:

DBS; IBZM-SPECT; dystonia; myoclonus

PMID:
22363319
PMCID:
PMC3282300
DOI:
10.3389/fneur.2012.00022
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Support Center