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Mar Drugs. 2012 Jan;10(1):116-8. doi: 10.3390/md10010116. Epub 2012 Jan 16.

Marine carotenoids and oxidative stress.

Abstract

Oxidative stress induced by reactive oxygen species plays an important role in the etiology of many diseases. Dietary phytochemical products, such as bioactive food components and marine carotenoids (asthaxantin, lutein, β-carotene, fucoxanthin), have shown an antioxidant effect in reducing oxidative markers stress. Scientific evidence supports the beneficial role of phytochemicals in the prevention of some chronic diseases. Many carotenoids with high antioxidant properties have shown a reduction in disease risk both in epidemiological studies and supplementation human trials. However, controlled clinical trials and dietary intervention studies using well-defined subjects population have not provided clear evidence of these substances in the prevention of diseases. The most important aspects of this special issue will cover the synthesis, biological activities, and clinical applications of marine carotenoids, with particular attention to recent evidence regarding anti-oxidant and anti-inflammatory properties in the prevention of cardiovascular disease.

KEYWORDS:

cardiovascular disease; coronary artery disease; marine carotenoids; oxidative stress; prevention; reactive oxygen species

PMID:
22363224
PMCID:
PMC3280526
DOI:
10.3390/md10010116
[Indexed for MEDLINE]
Free PMC Article
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