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Vasc Med. 2012 Feb;17(1):51-63. doi: 10.1177/1358863X11429175.

Polyunsaturated fatty acids and peripheral artery disease.

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  • 1Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94121, USA.


There is substantial evidence that polyunsaturated fatty acids (PUFAs) such as n-3 and n-6 fatty acids (FAs) play an important role in prevention of atherosclerosis. In vitro and in vivo studies focusing on the interactions between monocytes and endothelial cells have explored the molecular effects of FAs on these interactions. Epidemiological surveys, followed by large, randomized, control trials have demonstrated a reduction in major cardiovascular events with supplementation of n-3 FAs in secondary prevention settings. The evidence of beneficial effects specific to patients with peripheral artery disease (PAD) remains elusive, and is the focus of this review.

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