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Macromol Biosci. 2012 Apr;12(4):557-66. doi: 10.1002/mabi.201100383. Epub 2012 Feb 23.

Preparation of biodegradable polylactide microparticles via a biocompatible procedure.

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Institute for Bioengineering of Catalonia (IBEC) and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Edifici Helix, C/Baldiri Reixac 15-21, 08028 Barcelona, Spain.


PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 µm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.

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