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FEBS J. 2012 Apr;279(8):1407-13. doi: 10.1111/j.1742-4658.2012.08548.x. Epub 2012 Mar 23.

The signaling mechanism of ambient pH sensing and adaptation in yeast and fungi.

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1
Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan. maeda@iam.u-tokyo.ac.jp

Abstract

The four protein complexes termed endosomal sorting complexes required for transport (ESCRT) are key mediators of multivesicular body sorting/formation, retroviral budding and cell abscission, which share a membrane deformation process with the same topological change: vesicles budding away from the cytoplasm. Independent studies of the signal transduction pathways that mediate ambient pH sensing and adaptation in yeast and fungi revealed that these pathways share a conserved signaling mechanism that utilizes ESCRT complexes for its activation. This pathway in Saccharomyces cerevisiae, termed the Rim101 pathway, consists of both a sensing complex, which senses ambient alkaline pH, and a proteolytic complex, which proteolyzes and thereby activates the key transcription factor Rim101. Since the proteolytic complex is thought to be formed and activated on a platform of a multimerized ESCRT-III component Snf7, the organization, regulation and function of this pathway are dependent on the function of ESCRT complexes.

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