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Br J Surg. 2012 May;99(5):706-13. doi: 10.1002/bjs.8703. Epub 2012 Feb 22.

Surgical resection for non-familial adenomatous polyposis-related intra-abdominal fibromatosis.

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1
Sarcoma and Melanoma Unit, Department of Academic Surgery, Royal Marsden Hospital NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK. michelle.wilkinson@icr.ac.uk

Abstract

BACKGROUND:

Intra-abdominal fibromatosis (IAF) in the context of familial adenomatosis polyposis (FAP) is associated with significant morbidity and high recurrence rates after surgical resection. Non-surgical treatments are therefore advocated. This study explored outcomes in patients with IAF not associated with FAP who underwent surgical resection.

METHODS:

Data were analysed from a prospectively collected database at a sarcoma tertiary referral centre.

RESULTS:

From 2001 to 2011, 15 patients without FAP underwent primary curative surgical resection of IAF. Their median (range) age was 42 (19-64) years. Median tumour size was 18 (8.5-25) cm and weight 1306 (236-2228) g. Complete macroscopic clearance was obtained in all patients. There were no deaths in hospital or within 30 days and only one patient developed a major complication. Median follow-up was 40 (6-119) months. During follow-up two patients developed a recurrence after a disease-free interval of 12 and 16 months.

CONCLUSION:

In contrast to FAP-associated IAF, non-FAP-associated IAF has a very low recurrence rate after surgical resection. Surgical resection is therefore advocated as first-line treatment in patients with non-FAP-associated IAF when resection can be performed with low morbidity.

PMID:
22359346
DOI:
10.1002/bjs.8703
[Indexed for MEDLINE]
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