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J Infect Dis. 2012 Apr 1;205(7):1043-7. doi: 10.1093/infdis/jis026. Epub 2012 Feb 21.

Polymorphisms in the gene that encodes the iron transport protein ferroportin 1 influence susceptibility to tuberculosis.

Author information

1
Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Abstract

BACKGROUND:

We studied the association between iron intake and polymorphisms in the iron transporter gene SLC40A1 and the risk of tuberculosis.

METHODS:

We compared iron intake, the frequency of SLC40A1 mutations, and interactions among these variables among 98 tuberculosis patients and 125 controls in Kwazulu-Natal, South Africa.

RESULTS:

Four SLC40A1 single-nucleotide polymorphisms (SNPs) were associated with an increased risk of tuberculosis and 1 SNP with reduced risk. We also found a gene-environment interaction for 4 nonexonic SNPs and iron intake.

CONCLUSIONS:

This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence of an interaction between dietary iron and SLC40A1.

PMID:
22357659
DOI:
10.1093/infdis/jis026
[Indexed for MEDLINE]

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