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Sci Rep. 2012;2:256. doi: 10.1038/srep00256. Epub 2012 Feb 10.

Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease.

Abstract

An association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The association of DZIP1 with Parkinson's disease is discussed in the context of a Parkinson's disease stem-cell ageing theory.

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