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Sci Rep. 2011;1:152. doi: 10.1038/srep00152. Epub 2011 Nov 10.

Association of Kawasaki disease with tropospheric wind patterns.

Author information

1
Institut Català de Ciències del Clima (IC3), Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. xavier.rodo@ic3.cat

Abstract

The causal agent of Kawasaki disease (KD) remains unknown after more than 40 years of intensive research. The number of cases continues to rise in many parts of the world and KD is the most common cause of acquired heart disease in childhood in developed countries. Analyses of the three major KD epidemics in Japan, major non-epidemic interannual fluctuations of KD cases in Japan and San Diego, and the seasonal variation of KD in Japan, Hawaii, and San Diego, reveals a consistent pattern wherein KD cases are often linked to large-scale wind currents originating in central Asia and traversing the north Pacific. Results suggest that the environmental trigger for KD could be wind-borne. Efforts to isolate the causative agent of KD should focus on the microbiology of aerosols.

PMID:
22355668
PMCID:
PMC3240972
DOI:
10.1038/srep00152
[Indexed for MEDLINE]
Free PMC Article

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