Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Infect Dis. 2012 Apr;54(8):1179-86. doi: 10.1093/cid/cis033. Epub 2012 Feb 21.

Challenges for a universal Staphylococcus aureus vaccine.

Author information

1
Departments of Medical Microbiology/Immunology and Medicine, University of Wisconsin School of Medicine and Public Health School, Madison, USA. rap@facstaff.wisc.edu

Abstract

This review considers the reasons why the staphylococcal vaccine trials may have failed, based on new information about protective immunity against Staphylococcus aureus. The clinical trials and future vaccine candidate antigens are reviewed. Challenges facing the development of a universal S. aureus vaccine are also considered. The lack of a biomarker that is able to predict protection is a major stumbling block in the development of a staphylococcal vaccine. The major new information involves the role of cell-mediated immunity, specifically T-helper 17 cells and interleukin 17, as well as the lack of protection afforded by specific antibodies. This has major implications for future vaccine development and planning of clinical trials.

PMID:
22354924
DOI:
10.1093/cid/cis033
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center