Format

Send to

Choose Destination
Dev Dyn. 2012 Apr;241(4):663-74. doi: 10.1002/dvdy.23755. Epub 2012 Feb 21.

Asymmetric requirement of surface epithelial β-catenin during the upper and lower jaw development.

Author information

1
Department of Urology, Children's Hospital Boston, Boston, Massachusetts 02115, USA.

Abstract

BACKGROUND:

Intercellular communication between epithelial and mesenchymal cells is central to mammalian craniofacial development. β-catenin is the gateway of canonical Wnt signaling, one of the major evolutionarily conserved cell-cell communication pathways in metazoa. In this study, we report an unexpected stage- and tissue-specific function of β-catenin during mammalian jaw development.

RESULTS:

Using a unique mouse genetic tool, we have discovered that epithelial β-catenin is essential for lower jaw formation, while attenuation of β-catenin is required for proper upper jaw development. Changes in β-catenin in vivo alter major epithelial Fgf8, Bmp4, Shh, and Edn1 signals, resulting in partial transcriptional reprogramming of the neural crest-derived mesenchyme, the primary source of jawbones.

CONCLUSIONS:

The Wnt/β-catenin signal coordinates expression of multiple epithelial signals and has stage-specific asymmetric functions during mammalian upper and lower jaw development. In addition, these findings suggest that evolutionary changes of the canonical Wnt/β-catenin signaling pathway may lead to innovation of jaws.

PMID:
22354888
PMCID:
PMC3308359
DOI:
10.1002/dvdy.23755
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center