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Oral Maxillofac Surg. 2012 Jun;16(2):171-80. doi: 10.1007/s10006-012-0317-x. Epub 2012 Feb 22.

Oral field cancerization: current evidence and future perspectives.

Author information

1
KLE VK Institute of Dental Sciences and Hospital, Belgaum, 590010, Karnataka, India. punnya_angadi@rediffmail.com

Abstract

INTRODUCTION:

Oral field cancerization implies that oral cancer does not arise as an isolated cellular phenomenon but rather as an anaplastic tendency involving many cells at once and results in the multifocal development of cancer at various rates within the entire field in response to a carcinogen especially tobacco. This concept has been frequently used to explain the occurrence of multiple primary cancers and recurrences following complete excision of oral cancer.

DISCUSSION:

This review deals in detail with the origin, principle, various theories used to explain this effect and molecular, genetic, as well as cytogenetic findings related to oral field cancerization. Further, the clinical implications and future research directives are also discussed.

PMID:
22354325
DOI:
10.1007/s10006-012-0317-x
[Indexed for MEDLINE]

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