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Biochimie. 2012 Jul;94(7):1607-19. doi: 10.1016/j.biochi.2012.02.002. Epub 2012 Feb 13.

Fragment-based design of small RNA binders: promising developments and contribution of NMR.

Author information

1
CNRS, UMR 8638, Synthèse et structure de molécules d'intérêt pharmacologique, 4 avenue de l'Observatoire, 75006 Paris, France.

Abstract

Fragment-based drug design has become increasingly popular over the last decade. We review here the use of this approach to design small RNA binders. In addition, we discuss the use of NMR to detect the binding of small molecules on RNA targets and to guide chemists in the design of compounds targeting RNA.

PMID:
22353243
DOI:
10.1016/j.biochi.2012.02.002
[Indexed for MEDLINE]

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