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Genet Test Mol Biomarkers. 2012 Jun;16(6):508-13. doi: 10.1089/gtmb.2011.0248. Epub 2012 Feb 21.

Researcher and institutional review board chair perspectives on incidental findings in genomic research.

Author information

1
College of Nursing, The University of Iowa, Iowa City, Iowa 52242, USA. janet-williams@uiowa.edu

Abstract

AIMS:

Genomic research can produce findings unrelated to a study's aims. The purpose of this study was to examine researcher and Institutional Review Board (IRB) chair perspectives on genomic incidental findings (GIFs).

METHODS:

Nineteen genomic researchers and 34 IRB chairs from 42 institutions participated in semi-structured telephone interviews. Researchers and chairs described GIFs within their respective roles. Few had direct experience with disclosure of GIFs. Researchers favored policies where a case by case determination regarding whether GIF disclosure would be offered after discovery, whereas IRB chairs preferred policies where procedures for disclosure would be determined prior to approval of the research.

CONCLUSIONS:

Researcher and IRB chair perspectives on management of GIFs overlap, but each group provides a unique perspective on decisions regarding disclosure of GIFs in research. Engagement of both groups is essential in efforts to provide guidance for researchers and IRBs regarding disclosure of GIFs in research.

PMID:
22352737
PMCID:
PMC3378025
DOI:
10.1089/gtmb.2011.0248
[Indexed for MEDLINE]
Free PMC Article
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