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Hum Psychopharmacol. 2012 May;27(3):270-6. doi: 10.1002/hup.2219. Epub 2012 Feb 20.

Effects of prolonged-release melatonin and zolpidem on postural stability in older adults.

Author information

1
Forenap Pharma, Rouffach, France.

Abstract

OBJECTIVES:

A prolonged-release formulation of melatonin (PR-M) is indicated for insomnia in patients aged 55 years and older. Because hypnotics result in impairments of body sway, it was important to evaluate the effect of 2 mg PR-M on postural stability in older adults at night.

METHODS:

Twenty-four healthy volunteers (12 women, 12 men, aged 55-64 years) completed a randomized, double-blind, single-dose, three-way crossover study of postural stability of PR-M 2 mg, zolpidem 10 mg (active control) or placebo. Subjects were tested for body sway 30 min before, 1.5 and 4 h after dosing. Parameters tested were the area of the 95% confidence ellipse enclosing the center of pressure (COP; [A95]) and COP path length.

RESULTS:

Zolpidem significantly increased the A95 (both eyes conditions at all time points) and path length of COP. PR-M had no effect on A95 (both "eyes closed" and "eyes open" conditions at all time points) compared with placebo and increased COP path length by 10% at 4 h post-dose in open but not closed eyes condition. No serious adverse events were observed.

CONCLUSIONS:

In older adults, evening PR-M intake did not impair postural stability during the night. The postural instability with zolpidem demonstrated assay sensitivity and validated the outcome.

PMID:
22350925
DOI:
10.1002/hup.2219
[Indexed for MEDLINE]

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