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Amino Acids. 2012 Oct;43(4):1803-7. Epub 2012 Feb 17.

Creatine-induced glucose uptake in type 2 diabetes: a role for AMPK-α?

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School of Physical Education and Sports, University of Sao Paulo, Av Mello de Moraes, 65-Butantã, Sao Paulo, SP, 05508-030, Brazil.


This study focused on understanding the signaling mechanisms leading to GLUT-4 translocation and increased skeletal-muscle glucose uptake that follow creatine (Cr) supplementation in type 2 diabetes (n = 10). AMPK-α protein content presented a tendency to be higher (p = 0.06) after Cr supplementation (5 g/d for 12w). The changes in AMPK-α protein content significantly related (p < 0.001) to the changes in GLUT-4 translocation (r = 0.78) and Hb1Ac levels (r = -0.68), suggesting that AMPK signaling may be implicated in the effects of supplementation on glucose uptake in type 2 diabetes.

[Indexed for MEDLINE]

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