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Nat Prod Res. 2012;26(24):2363-7. doi: 10.1080/14786419.2012.662648. Epub 2012 Feb 21.

Antidiabetic effect of Eclipta alba associated with the inhibition of alpha-glucosidase and aldose reductase.

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1
Division of Biochemistry, Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow 226 001, Uttar Pradesh, India.

Abstract

The antidiabetic effect of the ethanolic extract of Eclipta alba (EEA) on hyperglycaemia and diabetic nephropathy was investigated in streptozotocin-induced diabetic rats. Single-dose treatment of EEA to streptozotocin-induced diabetic rats lowered the blood glucose level by 17.6% (p < 0.05) at 250 mg kg(-1) dose after 5 h post oral administration. Treatment of animals after 10 weeks of STZ-treatment with EEA (250 mg kg(-1)) for 21 days significantly reduced the elevated levels of blood glucose, %HbA1C, urea, uric acid and creatinine, and significantly increased the depressed serum insulin level. The extract exerted a significant inhibitory effect on alpha-glucosidase in a noncompetitive manner with an IC(50) value of around 54 µg mL(-1) and was found inhibitory to eye lens aldose reductase with an IC(50) value of around 4.5 µg mL(-1). The results suggest that EEA possesses antidiabetic effect associated with alpha-glucosidase and aldose reductase inhibition.

PMID:
22348789
DOI:
10.1080/14786419.2012.662648
[Indexed for MEDLINE]

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