Format

Send to

Choose Destination
J Microencapsul. 2012;29(5):455-62. doi: 10.3109/02652048.2012.658443. Epub 2012 Feb 21.

Microencapsulated drug delivery: a new approach to pro-inflammatory cytokine inhibition.

Author information

1
College of Pharmacy and Health Sciences, Mercer University, 3001 Mercer University Drive, Atlanta, GA 30341, USA. coettinger@aol.com

Abstract

CONTEXT:

This article reviews the use of albumin microcapsules 3-4 µm in size containing cytokine inhibiting drugs which include neutralizing antibodies to TNF and IL1, CNI-1493, antisense oligonucleotides to TNF and NF-kappaB, and the antioxidant catalase.

OBJECTIVE:

Describe the effects, cellular uptake and distribution of microencapsulated drugs and the effect in both a peritonitis model of infection and a model of adjuvant-induced arthritis.

METHODS:

The studies performed by our group are reviewed, the only such studies available.

RESULTS:

Microencapsulation of these compounds produced high intracellular drug concentrations due to rapid uptake by phagocytic cells, including endothelial cells, without toxicity. All compounds produced excellent inhibition of TNF and IL1 resulting in improved animal survival in a peritonitis model of septic shock and inflammation in an arthritis model.

CONCLUSION:

Albumin microencapsulated pro-inflammatory cytokine inhibiting compounds are superior to equivalent concentration of these compounds administered in solution form.

PMID:
22348221
PMCID:
PMC3433085
DOI:
10.3109/02652048.2012.658443
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center