Format

Send to

Choose Destination
Toxins (Basel). 2012 Jan;4(1):1-14. doi: 10.3390/toxins4010001. Epub 2011 Dec 30.

Investigations into the toxicology of spirolides, a group of marine phycotoxins.

Author information

1
AgResearch, Ruakura Research Centre, Private Bag, Hamilton 3123, New Zealand. rex.munday@agresearch.co.nz

Abstract

Spirolides are marine phycotoxins produced by the dinoflagellates Alexandrium ostenfeldii and A. peruvianum. Here we report that 13-desmethyl spirolide C shows little cytotoxicity when incubated with various cultured mammalian cell lines. When administered to mice by intraperitoneal (ip) injection, however, this substance was highly toxic, with an LD(50) value of 6.9 µg/kg body weight (BW), showing that such in vitro cytotoxicity tests are not appropriate for predicting the in vivo toxicity of this toxin. Four other spirolides, A, B, C, and 20-methyl spirolide G, were also toxic to mice by ip injection, with LD(50) values of 37, 99, 8.0 and 8.0 µg/kg BW respectively. However, the acute toxicities of these compounds were lower by at least an order of magnitude when administration by gavage and their toxic effects were further diminished when administered with food. These results have implications for future studies of the toxicology of these marine toxins and the risk assessment of human exposure.

KEYWORDS:

Alexandrium ostenfeldii; acute toxicity; marine phycotoxin; seafood poisoning; spirolides

PMID:
22347619
PMCID:
PMC3277094
DOI:
10.3390/toxins4010001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center