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Indian J Hum Genet. 2011 Sep;17(3):212-7. doi: 10.4103/0971-6866.92105.

Large-scale meta-analysis of genetic studies in ischemic stroke: Five genes involving 152,797 individuals.

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  • 1Laboratory of Human Genetics and Molecular Pathology, Facullty of medicine, UH2C - Casablanca, Morocco.

Abstract

BACKGROUND:

Ischemic stroke descent has a genetic basis. Stroke represents a complex trait, which is assumed to be polygenic. On this topic, the role of a wide number of candidate genes has been investigated in stroke through association studies.

MATERIALS AND METHODS:

We performed a literature-based systematic review of genetic association studies in stroke abound several populations. Odds ratios (ORs) and 95% confidence intervals (CIs) were determined for each gene-disease association. Following a review of 300 manuscripts, five candidate gene variants were analyzed among 152,797 individuals (45,433 cases and 107,364 controls).

RESULTS:

For these five candidate genes studied, the prothrombin OR is 1,57 (1,23-2,89), the factor V Leiden OR is 1,43 (0,67-6,24), the mean OR of angiotensin I converting enzyme (ACE) insertion/deletion (I/D) polymorphism is 1,11 (1,02-1,25), the summary OR for the C677T variant of 5,10-methylenetetrahydrofolate reductase (MTHFR) is 1,23 (0,61-1,47) and the pooled OR for the apolipoprotein E (APOE) gene is 0,95 (0,77-1,14) .

CONCLUSION:

These data suggest the genetic associations of some genes with ischemic stroke and it is necessary to compete with other genes. Our findings could represent an epidemiological base and a useful tool to address further molecular investigations and to realize more detailed meta-analyses.

KEYWORDS:

Angiotensin I converting enzyme; MTHFR; apolipoprotein E; factor II prothrombin; factor V Leiden; meta-analysis; stroke

PMID:
22345995
PMCID:
PMC3276992
DOI:
10.4103/0971-6866.92105
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